How Hydroxychloroquine and Azithromycin stop SARS-CoV-2 from killing you, and why some people don’t want you to know that.

Posted by on April 12, 2020 7:30 am
Categories: Misc Canadian News

Original Thread on Reddit (i think it will be removed, so i’m reposting here)

On April 11th, 2020, a medical professional (u/JamesColesPardon) explained to me that the empirical evidence is mounting that two drugs in combination are likely to prevent the lung damage that is the cause of death in patients having SARS-CoV-2 (the cause of Covid-19).

The drugs are Hydroxychloroquine and Azithromycin.

However, Trump already said about two weeks earlier that Hydroxychloroquine helps, so the media is suppressing this knowledge because they are afraid it will help Trump, and the medical elite are afraid to commission studies to get better evidence because they are afraid the results would help Trump. This also means that doctors are afraid to prescribe the drugs because those who hate Trump will cause trouble for them.

Like them, I did not believe Trump either, but unlike them, I also do not believe anyone else on TV, and also unlike them, I just go where the facts take me, so I am free to change as the evidence changes. We have an advantage over establishment experts because we do not have the conflicts of interest that establishment experts have.

That is a huge story itself, but this is an article about how the drugs work, so someone else will have to write about how those at the top would rather let people die than admit that Trump was right.

The drugs do not prevent infection or kill the virus, but they usually eliminate or greatly reduce the damage it indirectly causes to the lungs, which is how it kills people.

The main way it damages the lungs is that it causes what is known as a cytokine storm, which is where the immune system attacks everything at a certain location. About 7-10 days after infection, the immune system becomes extremely aggressive and starts destroying infected lung tissue, but of course, we do not want our immune system to attack our lungs like that.

To varying degrees, this happens in about one out of five who get the virus. Some of them don’t have serious symptoms, and yet may still get some lung damage.

The two ways that Hydroxychloroquine probably helps are:

  1. It alters the pH in the endosomes in cells so that they are no longer as susceptible to being hijacked to create virus RNA, which would get used to create more of the virus, which would then infect other cells. Altering the pH changes the folds and curves of the RNA molecules, which alters how they fit together, which impairs viral replication.

  2. “It does the same thing in an important immune system cell called the plasmacyatoid dendritic cell. What PDCs do is secrete TNF-alpha, an inflammatory cytokine, which signals to other cells that there is a problem. Normally, this is good. But in some people, the response becomes overwhelming, and what eventually happens is your body basically SWATs itself. What HC does is temporarily calms that response down, allowing humoral immunity (antibodies) to take over and do their job.”

The two ways that Azithromycin probably helps are:

  1. Azithromycin fights other pathogens that might also be present because of the patient’s weakened condition.

  2. “It also does this weird thing to another immune system cell – the macrophage.It turns macrophages from an M1 phenotype (super destroyer cells) to M2 phenotype (supportive wound healing cells).”

Related publications:

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro | Cell Discovery

Hydroxychloroquine Is Associated With Impaired Interferon-Alpha and Tumor Necrosis Factor-Alpha Production by Plasmacytoid Dendritic Cells in Systemic Lupus Erythematosus – PubMed

Azithromycin promotes alternatively activated macrophage phenotype in systematic lupus erythematosus via PI3K/Akt signaling pathway | Cell Death & Disease

Cytokine Storm: The Sudden Crash in Patients with COVID-19 | Physician’s Weekly